RT Journal Article
SR Electronic
A1 Nichols, Emma Hitt
T1 Novel Targets in Insulin Resistance and Type 2 Diabetes
JF MD Conference Express
YR 2013
FD SAGE Publications
VO 13
IS 11
SP 4
OP 5
DO 10.1177/155989771311001
UL http://mdc.sagepub.com/content/13/11/4.abstract
AB Patients with type 2 diabetes mellitus (T2DM) appear to have dysfunctional islet β cells due to unknown mechanisms [Leahy JL and Pratley RE. Translational Endo Metab 2011]. Multiple new pharmacologic agents that are under development for the treatment of T2DM specifically target islet cells. This article discusses two signaling pathways in β cells that may be important drug targets, the mechanisms underlying insulin resistance and potential drug targets, information on treating inflammation in adipose and skeletal tissues, as well as targeting mechanisms of glucose absorption and excretion in the treatment of T2DM.