RT Journal Article
SR Electronic
A1 Buckley, Rita
T1 TAFI(a) Assays Measure Extent of Activation in Patient Populations
JF MD Conference Express
YR 2013
FD SAGE Publications
VO 13
IS 13
SP 28
OP 29
DO 10.1177/155989771313014
UL http://mdc.sagepub.com/content/13/13/28.abstract
AB Assays for the activated form of thrombin activatable fibrinolysis Inhibitor(a) (TAFIa) can measure the extent of TAFI activation in patient populations. TAFI is a human plasma zymogen that is related to pancreatic carboxypeptidase B (CPB). The active form of TAFI (TAFIa), formed by thrombin cleavage of the zymogen, likely inhibits fibrinolysis by removal of the carboxyl-terminal lysine residues of partially degraded fibrin that stimulate plasminogen activation. TAFI is encoded by the CPB2 gene (chromosome 13) [Boffa MB et al. Biochemistry 1999]. This article presents insights into the function and regulation of TAFI.