PT  - JOURNAL ARTICLE
AU  - Kuznar, Wayne
ED  - Peyvandi, Flora
TI  - Protein Bioengineering Strategies Improve upon Hemophilia Treatments
DP  - 2013 Sep 01
TA  - MD Conference Express
PG  - 15--16
VI  - 13
IP  - 13
4099  - http://mdc.sagepub.com/content/13/13/15.short
4100  - http://mdc.sagepub.com/content/13/13/15.full
AB  - A new era in the treatment of hemophilia has emerged with a new generation of protein therapeutics. This article provides an overview of the future of coagulation factor replacement therapy. Protein engineering has increased the clinical potential and reduced rapid clearance of antihemophilic drugs from the body. Current therapy for hemophilia is safe and effective but immunogenic. Next generation antihemophilic drugs should have enhanced efficacy, greater safety, reduced immunogenicity, and improved delivery.