Summary

A feasibility study has provided new insight on the value of therapeutic anticoagulation for isolated distal deep vein thrombosis (IDDVT). This pilot study reported a nonsignificant trend toward reduction of serious complications, including the absence of major bleeding, with anticoagulation. The Anticoagulation of Calf Thrombosis trial [ACT; ISRCTN75175695] aimed to compare therapeutic anticoagulation against conservative management for patients with acute symptomatic IDDVT.