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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThrombus aspiration with percutaneous coronary intervention (PCI) did not improve mortality compared with PCI alone in patients with ST-elevation myocardial infarction in a large, randomized trial. This article presents data from the Thrombus Aspiration in ST-Elevation Myocardial Infarction in Scandinavia trial [TASTE; Fr\u00f6bert O et al. \u003Cem\u003EN Engl J Med 2013\u003C\/em\u003E].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EMyocardial Infarction\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EMyocardial Infarction\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EThrombus aspiration with percutaneous coronary intervention (PCI) did not improve mortality compared with PCI alone in patients with ST-elevation myocardial infarction (STEMI) in a large, randomized trial. Ole Fr\u00f6bert, MD, PhD, \u00d6rebro University Hospital, \u00d6rebro, Sweden, presented data from the Thrombus Aspiration in ST-Elevation Myocardial Infarction in Scandinavia trial [TASTE; Fr\u00f6bert O et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2013].\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003ECoronary artery thrombus aspiration performed in conjunction with PCI has been inconsistently demonstrated to improve blood flow and ST-segment elevation in patients with STEMI. The purpose of the TASTE trial was to evaluate the impact of thrombus aspiration in conjunction with PCI in patients with STEMI.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EIn the multicenter, prospective, registry-based TASTE trial, 7244 patients with STEMI were randomized to receive manual thrombus aspiration followed by PCI or PCI only. Patients with STEMI were eligible if they experienced symptoms for \u0026gt;30 minutes and \u0026lt;24 hours and STEMI or left bundle-branch block was confirmed on the electrocardiogram. Exclusion criteria were limited to age \u0026lt;18 years, previous randomization in the TASTE trial, and requirement for emergency coronary artery bypass grafting. The primary endpoint was time to all-cause mortality at Day 30. Secondary endpoints included time to rehospitalization with reinfarction at 30 days and time to stent thrombosis at 30 days. Prespecified analyses were performed in the intention-to-treat (ITT) population as well as a per-protocol population among those who received the actual treatment.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThe time from symptom onset to PCI was similar among both treatment arms with a mean of \u223c180 minutes. In the PCI plus thrombus aspiration arm, the cumulative risk of all-cause mortality was 2.8% compared with 3.0% in the PCI-only arm (HR, 0.94; 95% CI, 0.72 to 1.22; p=0.63) in the ITT analysis and (HR, 0.88; 95% CI, 0.66 to 1.17; p=0.38) in the per-protocol analysis [Fr\u00f6bert O et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2013].\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThe cumulative risk of rehospitalization due to reinfarction was 0.5% in the PCI plus thrombus aspiration arm compared with 0.9% in the PCI-only arm (HR, 0.61; 95% CI, 0.34 to 1.07; p=0.09) [Fr\u00f6bert O et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2013]. In addition, 0.2% of patients that received thrombus aspiration experienced stent thrombosis, compared with 0.5% of patients that received PCI only (HR, 0.47; 95% CI, 0.20 to 1.02; p=0.06). The rates of stroke, neurologic complications, perforation, tamponade, heart failure, or left ventricular dysfunction at hospital discharge were similar among both treatment arms [Fr\u00f6bert O et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2013].\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EProf. Fr\u00f6bert stated that, in his opinion, the data from the TASTE trial indicate that thrombus aspiration plus PCI does not reduce number of deaths or rehospitalization in patients with STEMI compared with PCI only. Therefore, Prof. Fr\u00f6bert suggested that there is likely no place for routine thrombus aspiration in conjunction with PCI in clinical practice.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2013 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/13\/15\/11.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nznmm2\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}