RT Journal Article
SR Electronic
A1 Rizzo, Toni
T1 Dabigatran Inferior to Warfarin in Patients with Mechanical Heart Valves
JF MD Conference Express
YR 2013
FD SAGE Publications
VO 13
IS 15
SP 10
OP 11
DO 10.1177/155989771315003
UL http://mdc.sagepub.com/content/13/15/10.abstract
AB Preclinical studies in porcine mechanical heart valve models suggested that dabigatran may effectively prevent valve thrombosis [Schomburg JL et al. J Invest Surg 2012]. These results led to A Randomized, Phase 2 Study to Evaluate the Safety and Pharmacokinetics of Oral Dabigatran Etexilate in Patients After Heart Valve Replacement [RE-ALIGN; Eikelboom JW et al. N Engl J Med 2013]. The aim of the RE-ALIGN trial was to evaluate a dosing algorithm of dabigatran based on the RE-LY study to prevent thromboembolic complications in patients with mechanical heart valve replacement.