RT Journal Article
SR Electronic
A1 Rizzo, Toni
T1 Role of iNKT Cells in Adipose Tissue Inflammation and Insulin Resistance
JF MD Conference Express
YR 2013
FD SAGE Publications
VO 13
IS 16
SP 10
OP 10
DO 10.1177/155989771316007
UL http://mdc.sagepub.com/content/13/16/10.1.abstract
AB This article, presents results of experiments which suggest that invariant natural killer T (iNKT) cells decrease the adipose tissue inflammation. A study using transgenic mice fed a high-fat diet reported that infiltration of human resistin-expressing macrophages into adipose tissue is a key mechanism for development of accelerated adipose tissue inflammation [Qatanani M et al. Clin Invest 2009]. Resistin interacts with CAP1 on macrophages, stimulating the secretion of inflammatory cytokines that interferes with the normal insulin signaling pathway, demonstrating that adipose tissue inflammation may mediate insulin resistance.