RT Journal Article
SR Electronic
A1 Mosley, Mary
T1 Storage of Dietary Fatty Acids in Type 2 Diabetes
JF MD Conference Express
YR 2013
FD SAGE Publications
VO 13
IS 16
SP 7
OP 8
DO 10.1177/155989771316004
UL http://mdc.sagepub.com/content/13/16/7.2.abstract
AB White adipose tissue is thought to be critical in controlling the amount of fat in lean tissue because it takes up excess dietary fat to prevent potentially toxic dietary fatty acids from being metabolized by lean tissue. At least 4 different mechanisms are thought to contribute to the deposition of ectopic fat: increased dietary fat, increase uptake of nonesterified fatty acids from white adipose tissue lipolysis, impaired fatty acid oxidation, and increased lipogenesis. This article reviews research to understand abnormal organ-specific postprandial storage of dietary fatty acids, and the impact of lifestyle intervention to reduce this storage.