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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThis article presents 1-year data from the Durable Polymer-Based Stent Challenge of Promus Element Versus Resolute Integrity in an All Comers Population [DUTCH PEERS (TWENTE II); von Birgelen C et al. \u003Cem\u003ELancet\u003C\/em\u003E 2013 (epublished ahead of print)] study. The results demonstrated comparable clinical outcomes with zotarolimus-eluting stents and everolimus-eluting stents (EES); both are third-generation, permanent, polymer-based, drug-eluting stents. There was no significant difference in efficacy and safety between the two stents, and longitudinal stent deformation was only seen in the EES group.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cul class=\u0022kwd-group clinical-trial\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology \u0026amp; Cardiovascular Medicine\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EClemens von Birgelen, MD, PhD, Thoraxcentrum Twente, Enschede, The Netherlands, presented 1-year data from the Durable Polymer-Based Stent Challenge of Promus Element Versus Resolute Integrity in an All Comers Population [DUTCH PEERS (TWENTE II); von Birgelen C et al. \u003Cem\u003ELancet\u003C\/em\u003E 2013 (epublished ahead of print)] study. The results demonstrated comparable clinical outcomes with zotarolimus-eluting stents (ZES) and everolimus-eluting stents (EES); both are third-generation, permanent, polymer-based, drug-eluting stents (DES). There was no significant difference in efficacy and safety between the two stents, and longitudinal stent deformation was only seen in the EES group.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe introduction of DES has constituted a major breakthrough in the field of interventional cardiology, markedly reducing the incidence of restenosis and morbidity [Karjalainen P, Nammas W. \u003Cem\u003EMinerva Cardioangiol\u003C\/em\u003E 2011]. Newer third-generation stent technology has been developed in an attempt to further enhance DES performance, and these durable-polymer-based DES aim to meet the need for more flexible and highly deliverable devices for the treatment of more challenging coronary lesions and vascular anatomy. While the coatings of third-generation stents remain similar to those of second-generation DES, changes in the material and design of their more flexible bare-metal platforms have the potential to reduce longitudinal stent stability.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003ETo date, however, long-term data to compare the efficacy of currently available third-generation DES are still lacking [Akin I et al. \u003Cem\u003EHerz\u003C\/em\u003E 2011].\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EDUTCH PEERS is a prospective, single-blinded, randomized, controlled trial in patients requiring percutaneous coronary intervention (PCI) with DES placement. The study was performed in 4 PCI centers in The Netherlands, and was designed to evaluate clinical outcomes after stenting with two third-generation DES that are frequently used clinically, but that had not previously been compared. It is the first all-comer trial with the platinum-chromium EES to be undertaken in a predominantly Caucasian population. A total of 20.4% of patients presented with a STEMI (requiring primary PCI), overall 58.6% had acute coronary syndromes, and 59.0% were treated for at lesions in small vessels.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EPatients were eligible to be included if they were aged \u226518 years, were able to provide informed consent, and had coronary artery disease and lesions eligible for DES treatment. There were no restrictions on clinical presentation or extent of coronary artery disease. Exclusion criteria included participation in another randomized clinical trial prior to reaching the primary endpoint; planned surgery within 6 months of PCI unless dual antiplatelet therapy was able to be continued during the surgery; pregnancy; life expectancy \u0026lt;1 year; and P2Y12 receptor antagonist intolerance, resulting in inability to adhere to dual antiplatelet therapy, or intolerance to heparin, aspirin, or components of the DES.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EThe primary endpoint was target vessel failure (TVF) at 1 year and was defined as the composite of cardiac death, target vessel-related myocardial infarction, or target vessel revascularization.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EA total of 1811 patients with 2371 target lesions were enrolled in the study and randomized to either treatment with third-generation cobalt-chromium ZES (n=906; 1205 lesions), or platinum-chromium EES (n=905; 1166 lesions).\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EAt 1 year, there was no statistically significant difference between the ZES and EES groups on the primary composite endpoint of TVF (6.1% vs 5.2%; p=0.42; p=0.006 for noninferiority; \u003Ca id=\u0022xref-fig-1-1\u0022 class=\u0022xref-fig\u0022 href=\u0022#F1\u0022\u003EFigure 1\u003C\/a\u003E), or in its individual components. Similarly, there was no significant difference between the two groups in the incidence of definite or probable stent thrombosis (0.6% vs 0.9%; p=0.4). There were no definite stent thromboses recorded at 3 months post implantation in either group. Longitudinal stent deformation was seen only in the EES group (1.0%; p=0.002) but not related to any adverse clinical events.\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/19\/22\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Primary Endpoint Data for DUTCH PEERS (TWENTE II)\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-747466260\u0022 data-figure-caption=\u0022Primary Endpoint Data for DUTCH PEERS (TWENTE II)\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/19\/22\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/19\/22\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/13\/19\/22\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/13785\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-10\u0022 class=\u0022first-child\u0022\u003EPrimary Endpoint Data for DUTCH PEERS (TWENTE II)\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003EReproduced with permission from C von Birgelen, MD.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-11\u0022\u003EProf. von Birgelen concluded that data from the DUTCH PEERS study demonstrate that treatment with either third-generation ZES or EES result in similar, clinical outcomes at 1 year.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2013 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/13\/19\/22.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nznkap\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nznkap\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}