RT Journal Article SR Electronic A1 Buckley, Rita T1 SPS3 Study Does Not Support the Use of Combination Therapy for Stroke Prevention JF MD Conference Express YR 2012 FD SAGE Publications VO 12 IS 1 SP 19 OP 20 DO 10.1177/155989771201011 UL http://mdc.sagepub.com/content/12/1/19.abstract AB Small subcortical strokes, also known as lacunar strokes, constitute more than 25% of brain infarcts and are the most common cause of vascular cognitive impairment. How to optimally prevent stroke recurrence and cognitive decline in patients with small subcortical stroke is unclear [Benevente OR et al. Int J Stroke 2011]. This article discusses results from The Secondary Prevention of Small Subcortical Strokes Study: The Antiplatelet Trial Results [SPS3; NCT00059306].