PT - JOURNAL ARTICLE AU - Buckley, Rita ED - Benavente, Oscar R. TI - SPS3 Study Does Not Support the Use of Combination Therapy for Stroke Prevention DP - 2012 May 01 TA - MD Conference Express PG - 19--20 VI - 12 IP - 1 4099 - http://mdc.sagepub.com/content/12/1/19.short 4100 - http://mdc.sagepub.com/content/12/1/19.full AB - Small subcortical strokes, also known as lacunar strokes, constitute more than 25% of brain infarcts and are the most common cause of vascular cognitive impairment. How to optimally prevent stroke recurrence and cognitive decline in patients with small subcortical stroke is unclear [Benevente OR et al. Int J Stroke 2011]. This article discusses results from The Secondary Prevention of Small Subcortical Strokes Study: The Antiplatelet Trial Results [SPS3; NCT00059306].