Summary

Small subcortical strokes, also known as lacunar strokes, constitute more than 25% of brain infarcts and are the most common cause of vascular cognitive impairment. How to optimally prevent stroke recurrence and cognitive decline in patients with small subcortical stroke is unclear [Benevente OR et al. Int J Stroke 2011]. This article discusses results from The Secondary Prevention of Small Subcortical Strokes Study: The Antiplatelet Trial Results [SPS3; NCT00059306].