RT Journal Article SR Electronic A1 Rizzo, Toni T1 The “New” Clinically Isolated Syndrome: To Treat or Not to Treat? JF MD Conference Express YR 2012 FD SAGE Publications VO 12 IS 2 SP 17 OP 18 DO 10.1177/155989771202012 UL http://mdc.sagepub.com/content/12/2/17.abstract AB Clinically isolated syndrome (CIS) refers to the first neurologic episode in which a person experiences multiple sclerosis (MS)-related symptoms. The diagnosis of CIS is reserved for patients who do not meet the criterion of dissemination in space and/or dissemination in time clinically and in the first magnetic resonance image. This article debates whether or not patients with CIS should be treated.