PT - JOURNAL ARTICLE AU - Rizzo, Toni ED - Hartung, Hans-Peter TI - The “New” Clinically Isolated Syndrome: To Treat or Not to Treat? DP - 2012 May 01 TA - MD Conference Express PG - 17--18 VI - 12 IP - 2 4099 - http://mdc.sagepub.com/content/12/2/17.short 4100 - http://mdc.sagepub.com/content/12/2/17.full AB - Clinically isolated syndrome (CIS) refers to the first neurologic episode in which a person experiences multiple sclerosis (MS)-related symptoms. The diagnosis of CIS is reserved for patients who do not meet the criterion of dissemination in space and/or dissemination in time clinically and in the first magnetic resonance image. This article debates whether or not patients with CIS should be treated.