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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThis article presents a case report of two sisters diagnosed with multiple sclerosis, one of whom developed sarcoidosis.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurological Autoimmune Diseases\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDemyelinating Diseases Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EPrevention \u0026amp; Screening\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EThe increased risk of a different autoimmune disorder occurring in the families of individuals who develop multiple sclerosis (MS) is well-recognized [Barcellos LF et al. \u003Cem\u003ELancet Neurol\u003C\/em\u003E 2006]. Such findings imply that certain genetic variants may increase susceptibility to autoimmune disease in general as opposed to influencing the development of one specific condition [International Multiple Sclerosis Genetics Consortium. \u003Cem\u003EGenes Immun\u003C\/em\u003E 2009]. A. Kuqo, University Neurology Service, Tirana, Albania, presented a case report of two sisters diagnosed with MS, one of whom developed sarcoidosis.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EA 46-year-old female was diagnosed 12 years earlier with relapsing-remitting MS according to McDonald Criteria [Polman CH et al. \u003Cem\u003EAnn Neurol\u003C\/em\u003E 2011]. Treatment with \u00df-interferon for a consecutive period of nine years significantly reduced relapses. Neurological conditions were stable, and the patient had a score of 3 on the Kurtzke Expanded Disability Status Scale. The patient\u0027s sister, also diagnosed with MS, was being treated by the same team. Three years prior, the original patient complained of arthralgia, conjunctivitis, and dry mouth. Immunological and biochemical laboratory studies were positive for sarcoidosis, a multisystem granulomatous disease that affects adults between 20 and 50 years old [Lopez V et al. \u003Cem\u003EInt J Dermatol\u003C\/em\u003E 2011].\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EAlthough available epidemiological data confirm that genetic factors are unequivocally relevant in MS, large extended families with multiple affected individuals are extremely uncommon [Sawcer S. \u003Cem\u003EAnn Indian Acad Neurol\u003C\/em\u003E 2009]. Most families contain no more than two or three affected individuals and no clear mode of inheritance can be inferred [Sawcer S. \u003Cem\u003EAnn Indian Acad Neurol\u003C\/em\u003E 2009].\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThese data suggest that genetic susceptibility to autoimmune disease may be a mosaic of common sets of pleiotropic alleles as well as effects specific to one or a few diseases [IMSGC. \u003Cem\u003EGenes Immun\u003C\/em\u003E 2009]. Further research is warranted to unravel the puzzle.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2012 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/12\/2\/8.3.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzni61\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}