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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThis article discusses the results from a poster from a study evaluating levels of cerebrospinal fluid and serum uric acid in multiple sclerosis patients compared with a control group.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ENeurology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDemyelinating Diseases\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EUric acid (UA) is an endogenous antioxidant [Guerrero AL et al. \u003Cem\u003ENeurol Sci\u003C\/em\u003E 2011], a natural scavenger of peroxynitrite [Liu B et al. \u003Cem\u003ENeurol Res\u003C\/em\u003E 2012]. Recent studies have found that multiple sclerosis (MS) patients have lower serum UA levels than controls [Liu B et al. \u003Cem\u003ENeurol Res\u003C\/em\u003E 2012].\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EGuerrero et al. demonstrated an association between lower UA levels in MS patients and clinical relapse. They also found an inverse correlation between lower serum UA levels and disability assessed by Expanded Diability Status Scale score [Guerrero AL et al. \u003Cem\u003ENeurol Sci\u003C\/em\u003E 2011]. F. Esfandiari, Neurology Research Institute, Kerma, Iran, presented a poster from a study evaluating levels of cerebrospinal fluid (CSF) and serum UA in MS patients compared with a control group.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EA total of 50 patients (30 with MS and 20 with noninflammatory neurological disease [NIND]) participated in the study. Controls were matched for age and sex. Descriptive statistics were presented as mean percentage \u00b1 SD. The \u003Cem\u003Et\u003C\/em\u003E-test was used to assess whether the means of the two groups were statistically different from each other. The authors performed all analyses using SPSS 17 (IBM, Armonk, New York, USA).\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EResults showed that the mean CSF UA in MS patients was 0.19 mg\/dL (SD=0.12) versus 0.24 mg\/dL (SD=0.189). Mean serum UA in MS patients was 3.95 mg\/dL (SD=1.24) versus 4.04 mg\/dL (SD=1.36) in the control group. In both groups, the relationship between CSF and UA was not significant (p=0.30). In addition, there was no significant difference between serum UA in the MS and the control group (p=0.83).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EThis study found no significant difference in CSF and serum UA between patients with MS and those in the control group. Future research is needed to determine the role of UA in the pathology and\/or treatment of MS.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2012 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/12\/2\/8.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nznhzd\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}