RT Journal Article
SR Electronic
A1 Vinall, Maria
T1 Pacemaker Therapy in Patients with Neurally Mediated Syncope and Documented Asystole
JF MD Conference Express
YR 2012
FD SAGE Publications
VO 12
IS 4
SP 14
OP 15
DO 10.1177/155989771204008
UL http://mdc.sagepub.com/content/12/4/14.abstract
AB This article presents evidence from the International Study on Syncope of Uncertain Etiology 3 Study [ISSUE3; NCT00359203], demonstrating that cardiac pacing therapy is effective for prevention of recurrent syncope in patients with neurally mediated syncope (NMS) and documented asystole. These data contradict previous data from two randomized trials [Connolly SJ et al. JAMA 2003; Raviele A et al. Eur Heart J 2004] that failed to prove the superiority of cardiac pacing over placebo for the prevention of syncopal recurrences in unselected patients who were affected by NMS.