PT  - JOURNAL ARTICLE
AU  - Rizzo, Toni
ED  - Allegra, Carmen Joseph
TI  - Effects of Prior Bevacizumab Use on Outcomes from the VELOUR Study
DP  - 2012 Jul 01
TA  - MD Conference Express
PG  - NP--NP
VI  - 12
IP  - 7
4099  - http://mdc.sagepub.com/content/12/7/NP.3.short
4100  - http://mdc.sagepub.com/content/12/7/NP.3.full
AB  - In the Phase 3 Aflibercept Versus Placebo in Combination With Irinotecan and 5-FU in the Treatment of Patients With Metastatic Colorectal Cancer After Failure of an Oxaliplatin Based Regimen [VELOUR; NCT00561470] trial, aflibercept plus FOLFIRI improved overall survival (OS) compared with FOLFIRI plus placebo in patients with metastatic colorectal cancer. This subgroup analysis of the VELOUR trial evaluated the consistency of aflibercept's effect on OS and progression-free survival in a prespecified analysis of patients previously treated with bevacizumab.