Inflammation and Fatty Degeneration in New Bone Formation in Patients with AS Treated with Anti-TNF Agents

Summary

When the inflammation of ankylosing spondylitis (AS) subsides, it may be replaced by repair tissue and fatty lesions, a process that leads to osteoproliferation and development of syndesmophytes. This article presents results from the European Ankylosing Spondylitis Infliximab Cohort [EASIC] study, an open-label extension of the Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy [ASSERT]. The objective of the EASIC study was to directly compare the effect of inflammation and fatty degeneration on the development of syndesmophytes in patients with AS after 5 years of anti-TNF therapy.

  • Rheumatology Clinical Trials
  • Inflammatory Disorders
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