PT - JOURNAL ARTICLE AU - Rizzo, Toni ED - Detert, Jacqueline TI - Adalimumab Plus Methotrexate versus Methotrexate Monotherapy in Early RA DP - 2012 Sep 01 TA - MD Conference Express PG - 16--16 VI - 12 IP - 9 4099 - http://mdc.sagepub.com/content/12/9/16.1.short 4100 - http://mdc.sagepub.com/content/12/9/16.1.full AB - This article presents results from the High Induction Therapy with Anti-Rheumatic Drugs study [HIT HARD], which compared treatment with adalimumab plus methotrexate with methotrexate monotherapy in disease-modifying antirheumatic drug (DMARD)-naïve patients with active early rheumatoid arthritis (RA). The central question of the study was whether or not early induction therapy with a subsequent step-down strategy leads to long-term clinical effect in patients with RA.