RT Journal Article
SR Electronic
A1 Buckley, Rita
T1 LITHE Study Subset: Identification of Tocilizumab Early Response-Associated Biomarkers
JF MD Conference Express
YR 2012
FD SAGE Publications
VO 12
IS 9
SP 15
OP 15
DO 10.1177/155989771209012
UL http://mdc.sagepub.com/content/12/9/15.abstract
AB The protein fragments that are generated from metalloproteinase (MMP)-mediated protein destruction are known as neoepitopes, which serve as biomarkers of inflammation in patients with rheumatoid arthritis (RA). The aim of Randomized, Double-Blind Study of Safety and Prevention of Structural Joint Damage During Treatment With Tocilizumab Versus Placebo, in Combination With Methotrexate, in Patients With Moderate to Severe Rheumatoid Arthritis study [LITHE; NCT00106535] was to identify biomarker profiles that are associated with early response to tocilizumab in patients with RA, using neoepitope markers.