RT Journal Article
SR Electronic
A1 Vinall, Phil
T1 GLP-1 Receptor Agonists and DPP-4 Inhibitors
JF MD Conference Express
YR 2012
FD SAGE Publications
VO 12
IS 10
SP 24
OP 26
DO 10.1177/155989771210011
UL http://mdc.sagepub.com/content/12/10/24.abstract
AB Incretins are hormones that stimulate insulin secretion in response to meals. Glucagon-like peptide-1 (GLP-1), an incretin secreted by enteroendocrine L-cells, stimulates insulin release, suppresses glucagon secretion, and reduces appetite, leading to the lowering of blood glucose. This article presents an overview of incretin-based therapies, and discussed the differences between the GLP-1RAs, as well as between dipeptidyl peptidase-4 inhibitors.