Summary

Type 1 diabetes mellitus increases the formation of long-lived complexes, known as advanced glycation endproducts (AGEs), which can contribute to the development of complications in patients with diabetes [Genuth S et al. Diabetes 2005]. AGEs accumulate naturally in tissues over time, and tissue burden is a function of chronological age. This article presents results of the “The Precocious “AGE—ing” Effect of Type 1 Diabetes in Children” study, which examined the relationship between chronological age and type 1 diabetes on skin AGEs in children.