RT Journal Article
SR Electronic
A1 Rizzo, Toni
T1 Incretins in Cardiovascular Disease
JF MD Conference Express
YR 2012
FD SAGE Publications
VO 12
IS 3
SP 8
OP 8
DO 10.1177/155989771203004
UL http://mdc.sagepub.com/content/12/3/8.1.abstract
AB This article discusses the potential benefits of incretin therapies in patients with cardiovascular disease. The 2 main incretin hormones are glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide. GLP-1 exerts beneficial effects on myocardial and endothelial function by inhibiting upregulation of reactive oxygen species and vascular cell adhesion molecule-1 mRNA in endothelial cells.