Summary

Percutaneous coronary intervention guided by fractional flow reserve plus the best available medical therapy (MT) improves outcomes in patients with stable coronary artery disease compared with optimal MT alone. The benefit is primarily due to a lower rate of rehospitalization for urgent revascularization. These findings, from the Fractional Flow Reserve-Guided Percutaneous Coronary Intervention Plus Optimal Medical Therapy versus Optimal Medical Therapy Alone in Patients with Stable Coronary Artery Disease [FAME 2; NCT01132495] trial.