RT Journal Article SR Electronic A1 Buckley, Rita T1 Novel Design Changes in DES Not Necessarily Better until Proven So JF MD Conference Express YR 2012 FD SAGE Publications VO 12 IS 8 SP 24 OP 24 DO 10.1177/155989771208012 UL http://mdc.sagepub.com/content/12/8/24.abstract AB A drug-eluting stent is a “combination product” in which changes to one component may affect others; small alterations to strut thickness and geometry, polymer, drug, dose, and kinetics may result in big outcome changes, for better or worse. This article discusses the many factors involved in the development and deployment of novel stents.