RT Journal Article
SR Electronic
A1 Vinall, Phil
T1 What Every Clinician Should Know about Emerging New Antimicrobials
JF MD Conference Express
YR 2012
FD SAGE Publications
VO 12
IS 14
SP 27
OP 27
DO 10.1177/155989771214012
UL http://mdc.sagepub.com/content/12/14/27.abstract
AB Macrocycles are molecules with a ringed architecture =12 atoms. They are flexible and have very good binding activity to their site of activity. Their functional groups can interact across a wide range of binding sites without losing activity or being pushed off. They are very potent and very selective. Many have good solubility, lipophilicity, metabolic stability, and bioavailability. However, some, such as fidaxomicin and rifaximin, are not very well absorbed. This article discusses the emerging macrocycles and their mode of action.