RT Journal Article
SR Electronic
A1 Vinall, Phil
T1 Targeting Gram-negative Superbugs with Polymyxins: From Lab-Bench to Bedside
JF MD Conference Express
YR 2012
FD SAGE Publications
VO 12
IS 14
SP 21
OP 22
DO 10.1177/155989771214009
UL http://mdc.sagepub.com/content/12/14/21.abstract
AB Extensively drug resistant Gram-negative superbugs Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae present a global medical challenge due to their resistance to almost all current antibiotics, and no new antibiotics will be available for many years to come. Frequently, the only active antibiotics currently in use are colistin (polymyxin E) and polymyxin B. This article presents an overview of how polymyxins kill Gram-negative superbugs and how resistance develops.