RT Journal Article
SR Electronic
A1 Vinall, Phil
T1 Effectiveness of the 10-Valent Pneumococcal NTHi Protein D Conjugate Vaccine against AOM
JF MD Conference Express
YR 2012
FD SAGE Publications
VO 12
IS 14
SP 16
OP 17
DO 10.1177/155989771214005
UL http://mdc.sagepub.com/content/12/14/16.abstract
AB Acute otitis media (AOM) is a common medical condition with high incidence in children <5 years of age [Monasta L et al. PLoS One 2012]. Accurate diagnosis is difficult and may partially explain differences in incidence rates in different studies and countries [Toll EC, Nunez DA. J Laryngol Otol 2012]. A trial with the 11-valent predecessor protein D conjugate vaccine demonstrated efficacy against AOM episodes caused by S. pneumoniae and NTHi [Prymula R et al. Lancet 2006]. This article presents preliminary data showing a trend toward positive vaccine effectiveness against AOM episodes for 10-valent pneumococcal nontypeable H. influenzae protein D conjugate vaccine in infants.