RT Journal Article SR Electronic A1 Vinall, Phil T1 Hot Topics in Early-Stage NSCLC Management JF MD Conference Express YR 2012 FD SAGE Publications VO 12 IS 15 SP 18 OP 19 DO 10.1177/155989771215013 UL http://mdc.sagepub.com/content/12/15/18.abstract AB The level of disease (single or multilevel), the absolute number of involved lymph nodes, the possible presence of bulky disease, and downstaging after induction can all have an impact on outcome and survival of non-small cell lung cancer (NSCLC). This article discusses factors that should be considered prior to surgery for stage III NSCLC, optimal radiotherapy combined with chemotherapy for stage III NSCLC, as well as a review of some of the data and ongoing trials for targeted agents in stage I to III NSCLC.