RT Journal Article
SR Electronic
A1 Rizzo, Toni
T1 Phase 3 Study of Crizotinib versus Pemetrexed or Docetaxel Chemotherapy in Patients with Advanced ALK-Positive NSCLC
JF MD Conference Express
YR 2012
FD SAGE Publications
VO 12
IS 15
SP 13
OP 14
DO 10.1177/155989771215010
UL http://mdc.sagepub.com/content/12/15/13.2.abstract
AB Although single-agent second-line chemotherapy has limited efficacy in unselected non-small cell lung cancer (NSCLC), its effect in advanced anaplastic Kinase positive (ALK+) NSCLC is uncertain. Crizotinib has marked clinical activity in ALK+ NSCLC [Camidge DR et al. Lancet Oncol 2012; Kim DW et al. ASCO 2012. Abstract 7533]. The PROFILE 1007 [NCT00932893] trial compared the efficacy and safety of crizotinib with standard chemotherapy as second-line therapy in patients with advanced ALK+ NSCLC.