RT Journal Article
SR Electronic
A1 Rizzo, Toni
T1 TAVR: From Concept to Clinical Reality
JF MD Conference Express
YR 2012
FD SAGE Publications
VO 12
IS 17
SP 12
OP 13
DO 10.1177/155989771217002
UL http://mdc.sagepub.com/content/12/17/12.abstract
AB This article chronicles the history and progress of aortic valve replacement (AVR). The development of AVR surgery gave patients the opportunity to live longer, feel better, and benefit from improved left ventricular function [Bonow RO et al. Circulation 2008]. However, clinical trials in the 2000s revealed that >30% of patients with severe symptomatic aortic stenosis were untreated because they were elderly, had comorbidities with high operative risk, or refused surgery [Iung B et al. Eur Heart J 2005; Charlson E et al. J Heart Valve Dis 2006; Bach DS et al. Circ Cardiovascular Qual Outcomes 2009].