RT Journal Article
SR Electronic
A1 Vinall, Phil
T1 Human Monoclonal Antibody for PCSK9 Lowers Cholesterol and Is Well Tolerated
JF MD Conference Express
YR 2012
FD SAGE Publications
VO 12
IS 18
SP 15
OP 19
DO 10.1177/155989771218009
UL http://mdc.sagepub.com/content/12/18/15.abstract
AB Proprotein convertase subtilisin kexin type 9 (PCSK9) is a circulating protein that plays a pivotal role in cholesterol homeostasis by reducing expression of low-density lipoprotein cholesterol (LDL-C) receptors by the liver, leading to diminished hepatic clearance capacity for plasma LDL-C and increased LDL-C levels in the blood [Cohen JC et al. N Engl J Med 2006; Lagace TA et al. J Clin Invest 2006; Benjannet S et al. J Biol Chem 2010]. AMG 145 is a fully human monoclonal antibody that blocks PCSK9 binding to the LDL receptor, improving LDL-C clearance and reducing circulating LDL-C concentration [Raal F et al. Circulation 2012].