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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThe Hydroxychloroquine Versus Placebo in Primary Sj\u00f6gren\u0027s Syndrome [JOQUER; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00632866\u0026amp;atom=%2Fspmdc%2F12%2F19%2F22.atom\u0022\u003ENCT00632866\u003C\/a\u003E] trial found no significant difference in the evolution of systemic disease activity, dryness, symptoms, and quality of life in patients treated with hydroxychloroquine when compared with placebo.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ERheumatology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ERheumatological Autoimmune Disorders\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EThe Hydroxychloroquine Versus Placebo in Primary Sj\u00f6gren\u0027s Syndrome [JOQUER; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00632866\u0026amp;atom=%2Fspmdc%2F12%2F19%2F22.atom\u0022\u003ENCT00632866\u003C\/a\u003E] trial found no significant difference in the evolution of systemic disease activity, dryness, symptoms, and quality of life (QoL) in patients treated with hydroxychloroquine (HCQ) when compared with placebo. The findings were presented by Jacques-Eric Gottenberg, MD, Strasbourg, University Hospital, Strasbourg, France, in a late-breaking clinical trial.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EHCQ is frequently prescribed for patients with primary Sj\u00f6gren\u0027s syndrome (pSS), notably for arthralgias, synovitis, or purpura but also only for dryness and fatigue; however, except for a small crossover trial (n=19), no controlled trial has evaluated HCQ versus placebo [Gottenberg JE. ACR 2012 Abstract l9]. JOQUER was a multicenter, randomized, double-blind, placebo-controlled trial in patients with pSS. To participate, patients were required to fulfill the American-European Consensus Group criteria for the diagnosis of pSS. Patients previously treated with HCQ and those with severe systemic manifestations were not eligible for the study. Eligible participants (n=120) were randomly assigned to receive HCQ 400 mg QD or placebo, and were followed up for 24 weeks. The primary endpoint was a \u226530% improvement in the values of 2 out of 3 of the patients\u0027 visual analog scale scores evaluating dryness, pain, and fatigue between Weeks 0 and 24. Secondary endpoints were the evolution of the European League Against Rheumatism (EULAR) Sj\u00f6gren\u0027s Syndrome Disease Activity Index (ESSDAI), EULAR Sj\u00f6gren\u0027s Syndrome Patient Reported Index (ESSPRI), dryness (Schirmer\u0027s test and unstimulated salivary flow), serum gammaglobulin levels, and QoL and symptom questionnaires.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EBaseline characteristics were similar between the 2 groups: mean age was 56 years, median disease duration was 5 years, anti-SSA\/SSB positivity was 55.1%, and median ESSDAI and ESSPRI were 2.3 and 6.2, respectively. At Week 24, 19.2% of placebo- and 19.6% of HCQ-treated patients had a favorable overall response (OR,1.07; 95% CI, 0.4 to 2.9; p=0.9; Figure 1). No significant difference was observed in the evolution of systemic disease activity, ocular or oral dryness, symptoms, and QoL. No significant difference was observed in patients with anti-SSA\/SSB autoantibodies, systemic involvement, or high immunoglobulin (Ig) G levels at enrollment. A significant decrease in IgM levels (from 1.3 g\/L to 1.1 g\/L) with HCQ versus no difference with placebo was noted (p=0.01). Nearly all evaluated patients in the HCQ group had detectable blood levels of HCQ at 6 months. Tolerance of HCQ was comparable to placebo.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EAs antimalarial drugs inhibit activation of endosomal toll-like receptors and interferon (IFN) [Kuznik A et al. \u003Cem\u003EJ Immunol\u003C\/em\u003E 2011], analyses are ongoing to determine whether HCQ could have a therapeutic interest in some patients with an IFN signature.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2012 MD Conference Express\u00ae\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/12\/19\/22.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzn5hd\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}