RT Journal Article
SR Electronic
A1 Vinall, Maria
T1 Anti-TGFβ Inhibits TGFβ-Regulated Gene Expression in Skin and Is Associated with a Rapid Decline in Skin Score
JF MD Conference Express
YR 2012
FD SAGE Publications
VO 12
IS 19
SP 21
OP 22
DO 10.1177/155989771219019
UL http://mdc.sagepub.com/content/12/19/21.2.abstract
AB In scleroderma, drug treatment of skin disease is difficult to assess due to the lack of easily measured endpoints. The modified Rodnan skin score (mRSS) is one method used to differentiate systemic sclerosis (SSc) disease subtypes, but it does not change much over short periods. This article discusses results from the Fresolimumab in Systemic Sclerosis [NCT01284322] study showing that transforming growth factor-β a-response genes correlate with the mRSS and may provide a means to more quickly assess drug efficacy for skin fibrosis in early phase trials.