PT - JOURNAL ARTICLE AU - Vinall, Maria ED - Barreto, Andrew D. TI - Combination Full-Dose IV-tPA + Argatroban is Safe and May Result in Higher Rates of Recanalization DP - 2011 Apr 01 TA - MD Conference Express PG - 17--18 VI - 11 IP - 1 4099 - http://mdc.sagepub.com/content/11/1/17.2.short 4100 - http://mdc.sagepub.com/content/11/1/17.2.full AB - Argatroban is a direct thrombin inhibitor that safely augments the benefit of tPA in animal stroke models; however, human data are limited. The Argatroban tPA Stroke Study [ARTSS; NCT00268762] is a multicenter, Phase II, prospective, open-label, safety and activity study of argatroban and tPA in patients with ischemic stroke.