RT Journal Article SR Electronic A1 Vinall, Maria T1 No Advantage for Percutaneous Closure of PFO versus Medical Therapy in Reducing Recurrent Neurological Events JF MD Conference Express YR 2011 FD SAGE Publications VO 11 IS 1 SP 16 OP 17 DO 10.1177/155989771101009 UL http://mdc.sagepub.com/content/11/1/16.abstract AB The CLOSURE I trial [NCT00201461] was conducted to determine if percutaneous patent foramen ovale closure using the STARFlex® Septal Closure System in combination with medical therapy, is superior to medical therapy alone to prevent recurrent ischemic neurological symptoms in patients with transient ischemic attack or ischemic stroke.