<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Alexander, Lori</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Human Recombinant Leptin for Treatment of Hypothalamic Amenorrhea</style></title><secondary-title><style face="normal" font="default" size="100%">MD Conference Express</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011-08-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">9-9</style></pages><abstract><style  face="normal" font="default" size="100%">Hypothalamic amenorrhea due to strenuous exercise or chronic energy deficiency is associated with the dysfunction of the hypothalamic-pituitary-peripheral axes, resulting in infertility, bone loss, and stress fractures. The findings of a pilot randomized controlled trial showed that long-term treatment with human recombinant leptin (metreleptin) improved neuroendocrine and reproductive function in women with exercise-induced hypothalamic amenorrhea and low levels of circulating leptin.</style></abstract><number><style face="normal" font="default" size="100%">5</style></number><volume><style face="normal" font="default" size="100%">11</style></volume></record></records></xml>