RT Journal Article
SR Electronic
A1 Alexander, Lori
T1 Insulin Resistance Has Independent Role in Atherogenesis
JF MD Conference Express
YR 2011
FD SAGE Publications
VO 11
IS 8
SP 28
OP 28
DO 10.1177/155989771108013
UL http://mdc.sagepub.com/content/11/8/28.abstract
AB In conditions with insulin resistance, it is well established that systemic abnormalities, such as dyslipidemia and hypertension, can effect cells in the vascular wall and cause atherosclerosis. Emerging research suggests that insulin resistance within vascular endothelial cells can lead directly to atherosclerosis independently of systemic factors. This effect is large and may be a major determinant of atherosclerosis in metabolic syndrome or type 2 diabetes.