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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThe Diabetes Prevention Program (DPP) was a multicenter trial that examined the impact of an intensive lifestyle intervention or metformin to prevent or delay the development of diabetes in a high-risk population with impaired glucose tolerance. The DPP ended early, demonstrating that lifestyle modification reduced diabetes onset by 58% versus 31% by metformin [Diabetes Prevention Program Research Group. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2002].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes \u0026amp; Endocrinology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EDiabetes Mellitus\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EPrevention \u0026amp; Screening\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EThe Diabetes Prevention Program (DPP) was a multicenter trial that examined the impact of an intensive lifestyle intervention or metformin to prevent or delay the development of diabetes in a high-risk population with impaired glucose tolerance (IGT). The DPP ended early, demonstrating that lifestyle modification reduced diabetes onset by 58% versus 31% by metformin [Diabetes Prevention Program Research Group. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 2002].\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe Diabetes Prevention Program Outcomes Study (DPPOS; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00038727\u0026amp;atom=%2Fspmdc%2F11%2F8%2F14.atom\u0022\u003ENCT00038727\u003C\/a\u003E) followed participants for another 7 years. The main objective was to assess the longer-term outcomes, including cost-effectiveness of the lifestyle and metformin interventions, with an intent-to-treat analysis that spanned the combined 10 years of DPP\/DPPOS. William H. Herman, MD, MPH, University of Michigan, Ann Arbor, Michigan, USA, presented findings from the study.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EData on resource utilization, cost, and quality of life (QoL) were collected prospectively during DPP and DPPOS. Economic analyses were performed from a health system perspective that considered direct medical costs. Sensitivity analyses were performed from a societal perspective that considered both direct medical costs and direct nonmedical costs (diet- and activity-related costs, participant time, and transportation).\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThe DPP randomized overweight adults with IGT and an elevated fasting glucose level to intensive lifestyle (ILS), metformin (MET), or placebo (PBO) for an average of 3 years. During the DPPOS, ILS and MET participants were encouraged to continue those interventions, and all were offered a modified lifestyle intervention.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EAn analysis demonstrated that the beneficial effects of ILS and MET on the incidence of type 2 diabetes persisted 10 years after randomization [DPP Research Group. \u003Cem\u003ELancet\u003C\/em\u003E 2009].\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EDuring DPP, the costs of ILS were greater than the cost of MET, which were greater than the cost of PBO. During DPPOS, the costs of ILS and MET were substantially lower than during DPP, and the costs of PBO were higher than during DPP.\u003C\/p\u003E\u003Cp id=\u0022p-8\u0022\u003EOver 10 years, the cumulative, undiscounted, per capita direct medical costs of the interventions were greater for ILS and MET than for PBO ($4601 ILS vs $2300 MET vs $769 PBO). The direct medical costs of care outside the DPP\/DPPOS increased over time for all groups but were highest for PBO. The cumulative undiscounted, per capita, direct medical costs of nonintervention-related medical care were greater for PBO ($27,468) than MET ($25,616) or ILS ($24,563).\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EThe undiscounted, per capita, total direct medical costs over 10 years were $29,164 for ILS, $25,616 for MET, and $28,236 for PBO. Quality of life was better for ILS compared with MET or PBO, and the undiscounted quality-adjusted life-years (QALYs) that accrued over 10 years were greater for ILS (6.81) than MET (6.69) or PBO (6.67). From a payer perspective, MET was less expensive and more effective than PBO, and ILS cost only about $1000 per QALY.\u003C\/p\u003E\u003Cp id=\u0022p-10\u0022\u003EFrom a payer perspective, the MET intervention was cost-saving, and the lifestyle intervention was cost-effective compared with PBO. The increased cost of the ILS, relative to PBO, was largely offset by lower nonintervention-related medical care costs. Health policy should support the funding of intensive lifestyle and metformin for diabetes prevention in high-risk adults.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2011 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/11\/8\/14.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzn1i1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}