RT Journal Article SR Electronic A1 Lake, Noelle T1 Emerging Resistance among Gram-Negative Pathogens: State of the Challenge JF MD Conference Express YR 2011 FD SAGE Publications VO 11 IS 12 SP 6 OP 7 DO 10.1177/155989771112002 UL http://mdc.sagepub.com/content/11/12/6.abstract AB In the 1980s, antimicrobial resistance among gram-negative (Gm) pathogens seemed to be under control. Much has since changed, and physicians are now facing unprecedented clinical challenges due to the growing proliferation of multidrug-resistant Gm pathogens. This article describes current epidemiological, mechanistic, and demographic trends that are related to this worldwide epidemic.