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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\u003Cp id=\u0022p-1\u0022\u003EChanges in common carotid artery intima-media thickness (IMT) are associated with stroke incidence in a multiethnic cohort, according to findings from the Multi-Ethnic Study of Atherosclerosis [MESA; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00005487\u0026amp;atom=%2Fspmdc%2F10%2F1%2F17.atom\u0022\u003ENCT00005487\u003C\/a\u003E] ancillary study for progression of IMT.\u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003Elipid disorders\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Eprevention \u0026amp; screening\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Ecerebrovascular disease\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003Eneurology clinical trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cdiv class=\u0022section\u0022 id=\u0022sec-1\u0022\u003E\u003Cp id=\u0022p-2\u0022\u003EChanges in common carotid artery intima-media thickness (IMT) are associated with stroke incidence in a multiethnic cohort, according to findings from the Multi-Ethnic Study of Atherosclerosis (MESA; \u003Ca class=\u0022external-ref external-ref-type-clintrialgov\u0022 href=\u0022\/lookup\/external-ref?link_type=CLINTRIALGOV\u0026amp;access_num=NCT00005487\u0026amp;atom=%2Fspmdc%2F10%2F1%2F17.atom\u0022\u003ENCT00005487\u003C\/a\u003E) ancillary study for progression of IMT. Common carotid artery IMT is used as a predictive measure for cardiovascular events and stroke. However, studies that investigated the association between common carotid artery IMT and stroke have demonstrated mixed results [Lorenz et al. \u003Cem\u003EStroke\u003C\/em\u003E 2006; Hollander et al. \u003Cem\u003EStroke\u003C\/em\u003E 2002; O\u0027Leary et al. \u003Cem\u003EN Engl J Med\u003C\/em\u003E 1999; Chambless et al. \u003Cem\u003EAm J Epidemiol\u003C\/em\u003E 2002]. Joseph F. Polak, MD, MPH, Tufts Medical Center, Boston, MA, presented findings from the MESA study.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe MESA study included 6814 individuals from 4 different ethnic groups (Caucasian-white, African-American, Chinese-American, and Hispanic-American) who were free of cardiovascular disease, without symptoms of atherosclerosis, and were capable of follow-up (median follow-up 3.0 years). The IMT progression substudy included 5640 participants. Ultrasonographies of the right common carotid artery were performed during two follow-up visits subsequent to the baseline visit. Ultrasonography studies included diameter curves, determined based on a 20-second-long series, and IMT measurements, determined from image selections at end-diastole.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe occurrence of stroke, defined as symptoms that lasted \u0026gt;24 hours or the detection of a clinically relevant lesion on brain imaging, was determined during the MESA follow-up visits or by phone interview, which was conducted every 9 to 12 months. Risk factors such as age, gender, systolic blood pressure, antihypertensive medications, cholesterol (high-density lipoprotein-HDL and low-density lipoprotein-LDL), diabetes, smoking, education, income, and ethnicity were also evaluated during this study, and Cox proportional hazards models were adjusted accordingly. Within this substudy, 39.5% of participants were Caucasian-white, 26.5% was African-American, 12.3% was Chinese-American, and 21.7% was Hispanic-American. The mean age was 64 years (range=46 to 88 years), and 52% was female.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EThis substudy revealed a mean rate of change in IMT of 0.015\u00b10.05 mm, and 48 stroke events were observed. The rate of change in common carotid artery IMT was associated with stroke incidence in this multiethnic cohort (HR, 1.282; 1.014 to 1.620; p=0.0376). Age (p=0.0085), systolic blood pressure (p=0.0012), and HDL-cholesterol (p=0.0055) were associated with the highest risk after Cox proportional hazards models adjustment.\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EHowever, there was a stronger association prior to risk factor adjustments. The nonadjusted mean common carotid artery IMT was 0.71\u00b10.19 mm for those with no stroke and 0.79\u00b10.17 mm for stroke (p=0.0025), and the rate of change in common carotid artery IMT was 0.01\u00b10.05 mm\/year for those with no stroke and 0.04\u00b10.07 mm\/year for stroke (p=0.0506). The most significant risk factors that were associated with stroke, according to the nonadjusted data, were age (p=0.0007), systolic blood pressure (123.1\u00b120.6 for no stroke and 138.8\u00b122.7 for stroke; p\u0026lt;0.0001), treatment with hypertension medication (p=0.0020), and HDL-cholesterol (52.0\u00b115.0 for no stroke and 46.5\u00b111.2 for stroke; p=0.0028).\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EThe results from the MESA study are promising with regard to the association between common carotid artery IMT and first-time stroke outcome. However, previous studies that investigated this association have yielded conflicting results. Therefore, additional studies are needed to support these findings.\u003C\/p\u003E\u003C\/div\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2010 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/10\/1\/17.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmu52\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}