RT Journal Article
SR Electronic
A1 Vinall, Maria
T1 Atherosclerosis Update: Development, Prevention/Stabilization, and Risk
JF MD Conference Express
YR 2010
FD SAGE Publications
VO 10
IS 2
SP 25
OP 26
DO 10.1177/155989771002017
UL http://mdc.sagepub.com/content/10/2/25.abstract
AB Inflammation plays a critical role in all phases of atherosclerosis, and it is triggered in part by lipid entry and retention and subsequent oxidation in the vessel walls. Most of the factors that contribute to plaque instability are related to lipid accumulation and subsequent inflammatory pathway activation. Changing the phenotype of the atherosclerotic lesions could increase plaque stability and reduce clinical events. This article discusses several interventions to reduce inflammation, as well as selected studies regarding the reduction of risk factors.