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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EThe Prospective Observational Longitudinal Registry of Patients with Stable Coronary Artery Disease [CLARIFY] study is a large (n=31,040) international trial that is aimed at evaluating outcomes and long-term prognostic determinants in outpatients with stable coronary artery disease, including heart rate, that adequately represent this contemporary population worldwide. This article discusses the significance of the CLARIFY trial as it applies to the Caribbean.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECoronary Artery Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EThe Prospective Observational Longitudinal Registry of Patients with Stable Coronary Artery Disease (CLARIFY) study is a large (n=31,040) international trial that is aimed at evaluating outcomes and long-term prognostic determinants in outpatients with stable coronary artery disease (CAD), including heart rate (HR), that adequately represent this contemporary population worldwide. Ronald Henry, MD, Regional Coordinator of the CLARIFY study, Trinidad and Tobago, discussed the significance of the CLARIFY trial as it applies to the Caribbean.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EWhile there is evidence that HR may be a prognostic indicator for cardiovascular (CV) outcomes, it has not yet been incorporated into CV risk assessment or therapeutic guidelines [Fox K et al. \u003Cem\u003ELancet\u003C\/em\u003E 2008]. Therefore, the CLARIFY registry offers a unique perspective regarding the role of HR in the setting of stable CAD, and this study may provide robust data about the disease presentation, risk management, and therapeutic strategies that are associated with HR. The prevalence of CAD has declined in developed countries, but this decline is offset by its increase in developing countries [Allender S et al. \u003Cem\u003EBritish Heart Foundation\u003C\/em\u003E 2007]. Thus, CLARIFY may offer solutions to help alleviate the disease burden in regions where CAD is increasing despite contemporary drug therapies, such as the Caribbean. Additionally, Caribbean involvement in this study allows for soft entry of the region into international CV studies while adding to the learning curve for regional networking. This involvement also fosters the alignment of clinical practices with regional or international guidelines.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EData will be collected at baseline and every 6 months over the course of 5 years. CLARIFY analyses will include demographic data; risk factors and lifestyle; medical history; physical examination and vital signs, including resting HR, measured by pulse palpation and standard 12-lead ECG; current symptoms; medications; and most recent laboratory (eg, fasting blood glucose, lipid panel) and CAD assessment measurements (eg, stress testing results, echocardiography, myocardial imaging), when available. This comprehensive analysis will provide important information on the demographic and clinical profiles of \u201creal-world\u201d outpatients with CAD. The HR data will potentially offer dynamic estimations of the changing patterns of HR management, disease presentation, and therapy and may help with the development of a reliable risk prediction tool that is based on HR. CLARIFY will improve knowledge about the contemporary CAD population and may help solidify the role of HR as a prognostic indicator. This study is ongoing, and results are expected in 2015.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2010 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/10\/7\/12.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmpqp\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}