Summary

Hypertension is a highly prevalent and powerful contributor to the growing worldwide burden of cardiovascular disease. Antihypertensive therapy significantly reduces the risk of cardiovascular morbidity and mortality that accompanies arterial hypertension. Despite the benefits of blood pressure reduction, approximately 70% of hypertensive adults worldwide are uncontrolled [Hajjar I et al. JAMA 2003]. This article discusses the emerging role of combination therapy in the management of difficult-to-treat hypertension.