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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/cdn\/css\/http\/css_Xg7z6oCTVgud_Q0huYz9x9iiD5H_2YPSJ5z2ZViSWdY.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EInjecting autologous stem cells directly into the hearts of patients with heart failure improves hemodynamic function, quality of life, and survival, according to new results from the STAR Heart study.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Genomics\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECardiology Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003EHeart Failure\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EInjecting autologous stem cells directly into the hearts of patients with heart failure improves hemodynamic function, quality of life, and survival, according to new results from the STAR Heart study. The open-label, nonrandomized study is the largest trial to date that has compared stem cell transplantation with standard therapy for patients with chronic heart failure due to ischemic heart disease.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe STAR Heart study included 391 patients with chronic heart failure, defined as a left ventricular ejection fraction (LVEF) \u226435%. All patients experienced myocardial infarction (MI) that was treated by percutaneous coronary intervention (PCI) for a mean of 8.5 years prior to study enrollment. A total of 191 patients agreed to undergo treatment with autologous stem cell transplantation, and the remaining 200 patients acted as controls. All patients were also receiving optimal medical therapy for heart failure.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe transplant procedure involved harvesting autologous stem cells from the bone marrow and delivering these cells (mean, 66 million) directly into the area of ischemic damage via intracoronary balloon catheter. Patients were examined at 3 months, 12 months, and 5 years after transplantation. Dr. Bodo-Eckehard Strauer, Heinrich-Heine-University of Duesseldorf, Duesseldorf, Germany, reported long-term results from the study.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EWithin 3 months, patients in the transplant group showed improvements in LV performance compared with baseline, including a 22% improvement in cardiac index (p\u0026lt;0.01), 15.4% increase in exercise capacity (p\u0026lt;0.01), 11% increase in peak oxygen update (p\u0026lt;0.05), and 6.3% increase in oxygen pulse (p\u0026lt;0.05). LVEF also increased by 22.4%, from 29.4% at baseline to 36% at 3 months (p\u0026lt;0.01). By comparison, all hemodynamic parameters worsened in the control group, including a 0.5% absolute reduction in LVEF (p\u0026lt;0.05).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EPatients in the transplant group sustained significant improvements in all measures of hemodynamics, exercise capacity, LV contractility, and LV geometry through the 5-year follow-up period. This included a 25.1% increase in LVEF (p\u0026lt;0.01), a 4.9% reduction in end diastolic volume (p\u0026lt;0.5), a 13.7% reduction in end systolic volume (p\u0026lt;0.01), and a 15.1% increase in shortening velocity (p\u0026lt;0.01). Patients in the control group showed a significant deterioration in each of these measures from baseline to 5 years (p\u0026lt;0.05 for all) despite optimal medical therapy.\u003C\/p\u003E\u003Cp id=\u0022p-7\u0022\u003EImprovements in LV performance were associated with prolonged survival among stem cell recipients. At 5 years, 184 of 191 patients were alive in the transplant group, compared with 168 of 199 control patients (p\u0026lt;0.01). Overall, these findings suggest a promising role for autologous stem cell transplantation in improving cardiac function and survival among patients with ischemic cardiomyopathy.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2010 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/10\/8\/10.1.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmoq1\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}