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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EDrug-eluting stents confer no additional late cardiovascular risk in patients with stenting of large coronary arteries when compared with bare-metal stents according to the results of the 24-month Basel Stent Cost-effectiveness Trial-PROspective Evaluation Examination [BASKET-PROVE; \u003Ca href=\u0022\/external-ref?link_type=ISRCTN\u0026amp;access_num=ISRCTN72444640\u0022 class=\u0022external-ref external-ref-type-isrctn\u0022\u003EISRCTN72444640\u003C\/a\u003E].\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003EInterventional Techniques \u0026amp; Devices Clinical Trials\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECoronary Artery Disease\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EDrug-eluting stents (DES) confer no additional late cardiovascular risk in patients with stenting of large coronary arteries when compared with bare-metal stents (BMS), reported Christoph Kaiser, MD, University Hospital, Basel, Switzerland. Prof. Kaiser presented the results of the 24-month Basel Stent Cost-effectiveness Trial-PROspective Evaluation Examination (BASKET-PROVE; \u003Ca href=\u0022\/external-ref?link_type=ISRCTN\u0026amp;access_num=ISRCTN72444640\u0022 class=\u0022external-ref external-ref-type-isrctn\u0022\u003EISRCTN72444640\u003C\/a\u003E).\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThe trial was designed to test the hypothesis that in large coronary arteries, first-generation DES provide only a small reduction in target vessel revascularization (TVR) and may increase late cardiac death\/myocardial infarction (MI). This study was designed after a retrospective analysis of the single-center BASKET\u2014Late Thrombotic Events (BASKET-LATE) trial, which examined the difference between first-generation DES and BMS among 826 patients, demonstrated that DES were associated with an increase in cardiac-related deaths or non-fatal MI after 6 months in patients with stenting of \u003Cem\u003Elarge\u003C\/em\u003E vessels. Of note, no such association was found in patients with \u003Cem\u003Esmall\u003C\/em\u003E vessels, however (Pfisterer M et al. \u003Cem\u003EEur Heart J\u003C\/em\u003E 2009), for which DES remain the stent of choice. A secondary aim of BASKET-PROVE was to determine whether a similar risk-benefit relationship would also be found for second-generation DES.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EThe study enrolled 2314 patients with vessels 3 mm in diameter and divided them into 3 groups: sirolimus-eluting (first-generation; SES) DES (n=775), everolimus-eluting (second-generation; EES) DES (n=774), and BMS (n=765). The mean patient age was 66 years, and 18% were diabetic. Patients represented a typical population that required stenting, with two-thirds presenting with acute coronary syndromes (34% with STEMI) and the remainder with stable chronic coronary artery disease. Patients were placed on aspirin therapy (75\u2013100 mg daily) indefinitely and on clopidogrel 75 mg daily for a minimum of 1 year.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003ECompliance with dual antiplatelet therapy was high (82%) at 1 year. After 2 years, there was no significant difference in the primary endpoint of cardiac death or nonfatal MI between the groups (2.6% for SES, 3.2% for EES, and 4.8% for BMS; p=0.13 SES vs BMS and p=0.37 EES vs BMS).\u003C\/p\u003E\u003Cp id=\u0022p-6\u0022\u003EAlso, there were no significant differences in the secondary endpoints of total death, noncardiac death, or stent thrombosis. However, there was a statistically significant difference in non-MI-related TVR between the DES patients and those who received the BMS (SES, p=0.007; EES, p=0.002), although there was no statistically significant difference between the two DES groups. This resulted in a significant difference in the composite of cardiac death, nonfatal MI, and TVR (MACE), which was significantly reduced by both of the DES (SES, p=0.009; EES, p=0.005). Limitations of the study include low overall number of events, resulting in reduced power to detect differences between groups (the 2.2% absolute difference in the primary endpoint between SES and BMS was not statistically different despite representing an \u223c85% relative increase), and unblinded adjudication of approximately one-third of reported events.\u003C\/p\u003E\u003Cdiv id=\u0022F1\u0022 class=\u0022fig pos-float  odd\u0022\u003E\u003Cdiv class=\u0022highwire-figure\u0022\u003E\u003Cdiv class=\u0022fig-inline-img-wrapper\u0022\u003E\u003Cdiv class=\u0022fig-inline-img\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/10\/15\/F1.large.jpg?width=800\u0026amp;height=600\u0026amp;carousel=1\u0022 title=\u0022Kaplan-Meier Estimates of Composite Primary Endpoint at 24 Months.\u0022 class=\u0022fragment-images colorbox-load\u0022 rel=\u0022gallery-fragment-images-1554161453\u0022 data-figure-caption=\u0022Kaplan-Meier Estimates of Composite Primary Endpoint at 24 Months.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003E\u003Cimg class=\u0022fragment-image\u0022 alt=\u0022Figure 1.\u0022 src=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/10\/15\/F1.medium.gif\u0022\/\u003E\u003C\/a\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cul class=\u0022highwire-figure-links inline\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/10\/15\/F1.large.jpg?download=true\u0022 class=\u0022highwire-figure-link highwire-figure-link-download\u0022 title=\u0022Download Figure 1.\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload figure\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022http:\/\/d282kpwvnogo5m.cloudfront.net\/content\/spmdc\/10\/10\/15\/F1.large.jpg\u0022 class=\u0022highwire-figure-link highwire-figure-link-newtab\u0022 target=\u0022_blank\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EOpen in new tab\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11359\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003Cdiv class=\u0022fig-caption attrib\u0022\u003E\u003Cspan class=\u0022fig-label\u0022\u003EFigure 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-7\u0022 class=\u0022first-child\u0022\u003EKaplan-Meier Estimates of Composite Primary Endpoint at 24 Months.\u003C\/p\u003E\n         \u003Cq class=\u0022attrib\u0022 id=\u0022attrib-1\u0022\u003ECopyright \u00a9 2010 Massachusetts Medical Society. All rights reserved.\u003C\/q\u003E\u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-8\u0022\u003E\u201cIn contemporaneous stenting of large coronary arteries, late safety problems with drug-eluting stents could not be confirmed, and there was even a trend in the opposite direction,\u201d said Dr. Kaiser. The findings, he noted, should influence medical practice.\u003C\/p\u003E\u003Cp id=\u0022p-9\u0022\u003EResults of this study were published simultaneously in \u003Cem\u003EThe New England Journal of Medicine\u003C\/em\u003E. Kaiser C et al. \u003Cem\u003EN Eng J Med\u003C\/em\u003E 2010.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2010 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/10\/10\/15.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_figures.js?nzmmyp\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmmyp\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}