RT Journal Article
SR Electronic
A1 Vinall, Phil
T1 Reperfusion Therapy in Acute Stroke: State-of-the-Art and Future Directions
JF MD Conference Express
YR 2009
FD SAGE Publications
VO 9
IS 1
SP 32
OP 33
DO 10.1177/155989770901021
UL http://mdc.sagepub.com/content/9/1/32.abstract
AB Reperfusion therapy with IV rt-PA and recanalization produces good outcomes in patients with acute stroke, but challenges remain. It is estimated that 85% of all ischemic strokes are not treated with thrombolysis; thus, improved and early access to treatment is needed. It is suggested that the 3 to 6-hour time window for treatment may be extended by better patient selection criteria using transcranial Doppler markers of the diffusion-perfusion mismatch method [Restrepo L et al. J Neuroimaging 2006] and combination therapies, such as reduced-dose rt-PA plus eptifibatide [Pancioli AM et al. Stroke 2008] or rt-PA plus GPIIb/IIIa antagonists.