PT  - JOURNAL ARTICLE
AU  - Vinall, Phil
ED  - Molina, Carlos A.
TI  - Reperfusion Therapy in Acute Stroke: State-of-the-Art and Future Directions
DP  - 2009 Apr 01
TA  - MD Conference Express
PG  - 32--33
VI  - 9
IP  - 1
4099  - http://mdc.sagepub.com/content/9/1/32.short
4100  - http://mdc.sagepub.com/content/9/1/32.full
AB  - Reperfusion therapy with IV rt-PA and recanalization produces good outcomes in patients with acute stroke, but challenges remain. It is estimated that 85% of all ischemic strokes are not treated with thrombolysis; thus, improved and early access to treatment is needed. It is suggested that the 3 to 6-hour time window for treatment may be extended by better patient selection criteria using transcranial Doppler markers of the diffusion-perfusion mismatch method [Restrepo L et al. J Neuroimaging 2006] and combination therapies, such as reduced-dose rt-PA plus eptifibatide [Pancioli AM et al. Stroke 2008] or rt-PA plus GPIIb/IIIa antagonists.