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type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/d282kpwvnogo5m.cloudfront.net\/sites\/default\/files\/advagg_css\/css__ce2QY63WIanKyr8eSq7eavr1XQRRmFD6ZSmwpyJi8lM__zXwFqpqmxrZOXXcd_TpBQpjuELbmIP9wBR5UuTDWAO4__YJWWMMdfCJuAFm5cUEp88OsodhO3ZA-2lzRfoBsSlk4.css\u0022 media=\u0022all\u0022 \/\u003E\n\u003Clink rel=\u0027stylesheet\u0027 type=\u0027text\/css\u0027 href=\u0027\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0027 \/\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-sageoa-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022 \u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup\u0022 \u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003Cdiv xmlns=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022 id=\u0022content-block-markup\u0022 xmlns:xhtml=\u0022http:\/\/www.w3.org\/1999\/xhtml\u0022\u003E\u003Cdiv class=\u0022article fulltext-view \u0022\u003E\u003Cspan class=\u0022highwire-journal-article-marker-start\u0022\u003E\u003C\/span\u003E\u003Cdiv class=\u0022section abstract\u0022 id=\u0022abstract-1\u0022\u003E\u003Ch2\u003ESummary\u003C\/h2\u003E\n            \u003Cp id=\u0022p-1\u0022\u003EAccording to standard emergency department (ED) guidelines, ischemic stroke patients must present to an ED within \u0026lt;3 hours of symptom onset to be eligible for rt-PA therapy. The European Cooperative Acute Stroke Study-3 [ECASS-3] expanded this eligibility window to 4.5 hours but with additional exclusion criteria. Even with this expanded time window, eligibility for rt-PA remains low\u2014about 9% versus 8% for the older time window.\u003C\/p\u003E\n         \u003C\/div\u003E\u003Cul class=\u0022kwd-group\u0022\u003E\u003Cli class=\u0022kwd\u0022\u003ENursing\u003C\/li\u003E\u003Cli class=\u0022kwd\u0022\u003ECerebrovascular Disease Clinical Trials\u003C\/li\u003E\u003C\/ul\u003E\u003Cp id=\u0022p-2\u0022\u003EAccording to standard emergency department (ED) guidelines, ischemic stroke patients must present to an ED within \u0026lt;3 hours of symptom onset to be eligible for rt-PA therapy. The European Cooperative Acute Stroke Study-3 (ECASS-3) expanded this eligibility window to 4.5 hours but with additional exclusion criteria. Dawn Kleindorfer, MD, University of Cincinnati Hospital Neuroscience Institute, Cincinnati, OH, presented data in a poster that showed that even with this expanded time window, eligibility for rt-PA remains low\u2014about 9% versus 8% for the older time window.\u003C\/p\u003E\u003Cp id=\u0022p-3\u0022\u003EThis retrospective, observational study reviewed the primary\/secondary hospital ICD-9-CM codes 430 to 436 from the year 1999 at 17 acute care hospitals in the greater Cincinnati\/Northern Kentucky region. Of the 2441 ischemic stroke patients who were identified, 1968 presented to an ED. Fifty-four percent (54%) of these patients were female, 19% were black, and 80% were white. The mean age of the patients was 72 years.\u003C\/p\u003E\u003Cp id=\u0022p-4\u0022\u003EIn addition to the standard medical, time, and severity exclusions for rt-PA, the ECASS-3 excludes patients who are aged \u0026gt;80 years, those with an NIHSS score \u0026gt;25, those who have both diabetes mellitus and prior stroke history, and patients who have been given previous anticoagulant therapy. The purpose of the study was to compare the number of patients that is eligible for rt-PA therapy using the standard and revised ECASS-3 time frames and exclusion criteria.\u003C\/p\u003E\u003Cp id=\u0022p-5\u0022\u003EOf the 2441 adult inpatient and out-of-hospital ascertained ischemic strokes, 1968 presented to an emergency department (81%) in 1999, 519 (22%) arrived in the ED in \u0026lt;3 hours from symptom onset and 87 (3.6%) arrived in 3 to 4.5 hours. Of the patients who arrived at the ED in \u0026lt;3 hours, 225 (11.4%) were eligible for standard regimen rt-PA, which is 9.2% of all ischemic stroke patients. Of the 87 patients who arrived between 3 and 4.5 hours, 23 (0.94%) were eligible using standard rt-PA exclusions, and only 24 (1.2%) would have been eligible using the additional exclusion criteria from the ECASS-3. Prevalence of the exclusion criteria for the 3 to 4.5 hour patients are listed in \u003Ca id=\u0022xref-table-wrap-1-1\u0022 class=\u0022xref-table\u0022 href=\u0022#T1\u0022\u003ETable 1\u003C\/a\u003E.\u003C\/p\u003E\u003Cdiv id=\u0022T1\u0022 class=\u0022table pos-float\u0022\u003E\u003Cdiv class=\u0022table-inline\u0022\u003E\u003Cdiv class=\u0022callout\u0022\u003E\u003Cspan\u003EView this table:\u003C\/span\u003E\u003Cul class=\u0022callout-links\u0022\u003E\u003Cli class=\u00220 first\u0022\u003E\u003Ca href=\u0022\/\u0022 class=\u0022table-expand-inline\u0022 data-table-url=\u0022\/highwire\/markup\/11422\/expansion?postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media%2Chighwire_embed\u0026amp;table-expand-inline=1\u0022 html=\u00221\u0022 fragment=\u0022#\u0022 external=\u00221\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView inline\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00221\u0022\u003E\u003Ca href=\u0022\/highwire\/markup\/11422\/expansion?width=1000\u0026amp;height=500\u0026amp;iframe=true\u0026amp;postprocessors=highwire_figures%2Chighwire_math%2Chighwire_inline_linked_media\u0022 class=\u0022colorbox colorbox-load table-expand-popup\u0022 rel=\u0022gallery-fragment-tables\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView popup\u003C\/a\u003E\u003C\/li\u003E\u003Cli class=\u00222 last\u0022\u003E\u003Ca href=\u0022\/highwire\/powerpoint\/11422\u0022 class=\u0022highwire-figure-link highwire-figure-link-ppt\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EDownload powerpoint\u003C\/a\u003E\u003C\/li\u003E\u003C\/ul\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cdiv class=\u0022table-caption\u0022\u003E\u003Cspan class=\u0022table-label\u0022\u003ETable 1.\u003C\/span\u003E \n            \u003Cp id=\u0022p-6\u0022 class=\u0022first-child\u0022\u003EEligibility for rt-PA within a Population of Ischemic Stroke Patients Arriving 3 to 4.5 Hours After Symptom Onset.\u003Csup\u003E*\u003C\/sup\u003E\n            \u003C\/p\u003E\n         \u003Cdiv class=\u0022sb-div caption-clear\u0022\u003E\u003C\/div\u003E\u003C\/div\u003E\u003C\/div\u003E\u003Cp id=\u0022p-10\u0022\u003EDr. Kleindorfer concluded that the ECASS-3 expanded time window does not increase stroke patient eligibility for rt-PA very much since the majority of hyperacute patients arrives at the ED in \u0026lt;2 hours. She estimated that only an additional 0.94% of all stroke patients would have been eligible using the expanded ECASS-3 criteria. The ECASS-3 criteria excludes a significant portion of stroke patients, especially those aged \u0026gt;80 years (31%). However, the increased time window may still have an impact on rt-PA treatment rates and should not be ignored.\u003C\/p\u003E\u003Cul class=\u0022copyright-statement\u0022\u003E\u003Cli class=\u0022fn\u0022 id=\u0022copyright-statement-1\u0022\u003E\u00a9 2009 MD Conference Express\u003C\/li\u003E\u003C\/ul\u003E\u003Cspan class=\u0022highwire-journal-article-marker-end\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Cspan id=\u0022related-urls\u0022\u003E\u003C\/span\u003E\u003C\/div\u003E\u003Ca href=\u0022http:\/\/mdc.sagepub.com\/content\/9\/1\/21.abstract\u0022 class=\u0022hw-link hw-link-article-abstract\u0022 data-icon-position=\u0022\u0022 data-hide-link-title=\u00220\u0022\u003EView Summary\u003C\/a\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_openurl.js?nzmlkq\u0022\u003E\u003C\/script\u003E\n\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/mdc.sagepub.com\/sites\/all\/modules\/highwire\/highwire\/plugins\/highwire_markup_process\/js\/highwire_tables.js?nzmlkq\u0022\u003E\u003C\/script\u003E\n\u003C\/body\u003E\u003C\/html\u003E"}